Equipotent to Ins(1,4,5)P3 in releasing intracellular calcium. The 3-position is blocked by fluorine, hence it cannot be converted to Ins(1,3,4,5)P4 by the action of 3-kinases. It may therefore provide a useful tool for studying the complex biochemical pathways in which InsP3 and InsP4 are closely interactive.
Product Details
| Alternative Name: | 3-F-Deoxy-Ins(1,4,5)P3 . 6Na |
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| Formula: | C6H8FO14P3 . 6Na |
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| MW: | 416.0 . 137.9 |
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| CAS: | 129365-68-0 |
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| Purity: | ≥99% (31P-NMR) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Synthesis of the First Optically Pure, Fluorinated Inositol 1,4,5-Trisphosphate of myo-Inositol Stereochemistry and Its Effect on Ca2+ Release in Swiss 3T3 Cells: A.P. Kozikowski, et al.; JACS 112, 7403 (1990),
