Replaces Prod. #: BML-CA430
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
Product Details
Alternative Name: | Ins(1,4,5)P3 . 6K, IP3 |
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Formula: | C6H9O15P3 . 6K |
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MW: | 414.1 . 234.6 |
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CAS: | 103476-24-0 |
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Purity: | ≥98% (TLC) |
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Appearance: | White to off-white powder. |
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Solubility: | Soluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Protect from light and moisture. Hygroscopic. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis: M.P. Marciel, et al.; Oncotarget
9, 13407 (2018),
Abstract;
Full Text
Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand: Z. Ding, et al.; Mol. Pharmacol.
77, 995 (2010),
Abstract;
Synthetic partial agonists reveal key steps in IP3 receptor activation: A.M. Rossi, et al.; Nat. Chem. Biol.
5, 631 (2009),
Abstract;
Full Text
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor: M. Auger-Messier, et al.; Mol. Endocrinol.
18, 2967 (2004),
Abstract;
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Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase: B. Gonzalez, et al.; Mol. Cell
15, 689 (2004),
Abstract;
Full Text
Inositol 1,4,5-trisphosphate-activated calcium channels: C.D. Ferris & S.H. Snyder; Annu. Rev. Physiol.
54, 469 (1992),
Abstract;
Inositol trisphosphate and diacylglycerol: two interacting second messengers: M.J. Berridge, et al.; Annu. Rev. Biochem.
56, 159 (1987),
Abstract;
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver: S.K. Joseph, et al.; J. Biol. Chem.
259, 3077 (1984),
Abstract;