Stable, membrane permeable inhibitor of farnesyltransferase. Has 30-fold higher selectivity for farnesyltransferase over geranylgeranyltransferase. Potential anticancer drug.
Product Details
| Alternative Name: | B581 |
| |
| Sequence: | N-[(2S)-((2R)-Amino-3-mercaptopropylamino)-3-methylbutyl]-Phe-Met-OH |
| |
| Formula: | C22H38N4O3S2 |
| |
| MW: | 470.7 |
| |
| CAS: | 149759-96-6 |
| |
| Purity: | ≥90% (HPLC) |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in water or DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Hygroscopic. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion: S.E. Collins, et al.; Mol. Biol. Cell
34, ar9 (2023),
Abstract;
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: A.M. Garcia, et al.; J. Biol. Chem.
268, 18415 (1993),
Abstract;
Full Text
