Stable, membrane permeable inhibitor of farnesyltransferase. Has 30-fold higher selectivity for farnesyltransferase over geranylgeranyltransferase. Potential anticancer drug.
Product Specification
| Alternative Name: | B581 |
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| Sequence: | N-[(2S)-((2R)-Amino-3-mercaptopropylamino)-3-methylbutyl]-Phe-Met-OH |
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| Formula: | C22H38N4O3S2 |
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| MW: | 470.7 |
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| CAS: | 149759-96-6 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: A.M. Garcia, et al.; J. Biol. Chem.
268, 18415 (1993),
Abstract;
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