Precursor of malondialdehyde (MDA), a naturally occuring product of lipid peroxidation and prostaglandin biosynthesis, which is also formed by oxidation of polyunsaturated fatty acids in foods. Reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine.
Product Details
| Alternative Name: | Malondialdehyde Precursor, MDA Precursor, 1,1,3,3-Tetramethoxypropane |
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| Formula: | C7H16O4 |
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| MW: | 164.2 |
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| CAS: | 102-52-3 |
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| MI: | 13: 5709 (Malondialdehyde (MDA)) |
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| Purity: | ≥98% (GLC) |
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| Identity: | Identity determined by IR. |
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| Appearance: | Colorless liquid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Keep away from heat, sources of ignition and incompatibles such as oxidizing agents. |
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| Technical Info/Product Notes: | Malondialdehyde (MDA) is very hygroscopic and can be stored only for a short time. For biological experiments we recommend to use aqueous solutions of MDA freshly prepared by acid hydrolysis (1% H2SO4 at room temperature) of malonaldehyde bis(dimethyl acetal) (Prod. No. ALX-280-018). |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chemistry and biology of DNA damage by malondialdehyde: L.J. Marnett, et al.; IRAC Sci. Publ.
150, 17 (1999),
Abstract;
Lipid peroxidation-DNA damage by malondialdehyde: L.J. Marnett, et al.; Mutat. Res.
424, 83 (1999),
Abstract;
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes: H. Esterbauer, et al.; Free Radic. Biol. Med.
11, 81 (1991),
Abstract;
Malonaldehyde in aqueous solution and its role as a measure of lipid oxidation in foods: T. W. Kwon, et al.; J. Food Sci. 29, 294 (1964),
