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SMI-4a

Pim1 inhibitor
 
ALX-270-515-M005 5 mg 125.00 USD
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Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitocondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

Product Details

Formula:C11H6F3NO2S
 
MW:273.2
 
CAS:327033-36-3
 
Purity:≥95% (HPLC, TLC, NMR/ELSD)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (at least 5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
270-515
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Product Literature References

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.W. Lin, et al.; Blood 115, 824 (2010), Abstract;
Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; J. Biol. Chem. 285, 29128 (2010), Abstract; Full Text
Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther. 8, 1473 (2009), Abstract; Full Text
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther. 8, 846 (2009), Abstract; Full Text
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem. 52, 74 (2009), Abstract;

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