Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression.
Product Details
| Formula: | C21H18N2O3 |
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| MW: | 346.4 |
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| Source: | Synthetic derivative of Nb-(p-feruloyl)serotonin from Phragmites communis extract. |
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| Purity: | ≥95% (NMR) |
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| Identity: | Identity determined by 1H- & 13C-NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (at least 5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MS-1020 is a novel small molecule that selectively inhibits JAK3 activity: B.H. Kim, et al.; Br. J. Haematol.
148, 132 (2010),
Abstract;
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Suppression of Autoimmune Arthritis by Small Molecule
Inhibitors of the JAK/STAT Pathway: C.J. Malemud; Pharmaceuticals
3, 1446 (2010),
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