Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

(S)-CR8

Inhibitor of CDK and GSK
 
ALX-270-509-M005 5 mg 278.00 USD
Do you need bulk/larger quantities?
 
Potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, 7 and 9. Two to four-fold more potent inhibitor of CDKs than (R)-roscovitine (Prod. No. BML-CC205). Induces apoptotic cell death more potently than (R)-roscovitine. Equally potent inhibitor of CDKs as (R)-CR8. Less potent glycogen synthase kinase (GSK-3α/β) inhibitor than (R)-CR8.

Product Details

Formula:C24H29N7O
 
MW:431.5
 
Source:Synthetic.
 
CAS:1084893-56-0
 
Purity:≥97% (NMR)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient Temperature
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
Scientific Background:The 20 cyclin-dependent kinases (CDKs) belong to an extensively studied and well-conserved family of kinases. Experiments have shown that thirteen of the 20 CDKs are activated by the binding of the regulatory partner cyclin. In conjunction with cyclins and through complex pathways, CDKs regulate diverse key transitions of the cell division cycle. A plethora of abnormalities in the regulation and activity of CDKs have been described in various tumors.
 
Regulatory Status:RUO - Research Use Only
 
270-509
Please mouse over
270-509

Product Literature References

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008), Abstract;

Related Products

(R)-Roscovitine 

CDK inhibitor
186692-46-6, ≥95% (HPLC, TLC) | Print as PDF
 
BML-CC205-0002 2 mg 93.00 USD
 
BML-CC205-0005 5 mg 214.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Stem Cells
Stem Cells
Download as PDF

All new literature pieces