Cell permeable inhibitor human (IC50=4µM), fission yeast (IC50=5µM), S. cerevisiae (IC50=12µM) and bovine (IC50=17µM) Arp2/3 complex between Arp2 and Arp3. Inhibits Listeria motility (IC50=7µM).
Product Details
| Alternative Name: | 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide |
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| Formula: | C18H17FN2O |
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| MW: | 296.3 |
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| CAS: | 442633-00-3 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to tan-yellow solid. |
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| Solubility: | Soluble in DMSO (a minimum concentration of 5 mg/ml is recommended). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun.
10, 969 (2019),
Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito,
Abstract;
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Characterization of two classes of small molecule inhibitors of Arp2/3 complex: B.J. Nolen, et al.; Nature
460, 1031 (2009),
Abstract;
General Literature References
Arp2 links autophagic machinery with the actin cytoskeleton: I. Monastyrska, et al.; Mol. Biol. Cell
19, 1962 (2008),
Abstract;
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