Cell permeable modulator of actin-related protein 3 (Arp3). Inserts into the hydrophobic core of Arp3 and alters its conformation. Inhibits human and Bos taurus Arp2/3 complex, actin polymerization (IC50=11µM) and the formation of podosomes.Inhibits polymerization (IC50=31µM), stimulated by ActA, a comet tail formation inducer from Listeria monocytogenes.
Product Details
| Alternative Name: | 2-(3-Bromophenyl)-3-(5-chloro-2-hydroxy-phenyl)thiazolidin-4-one |
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| Formula: | C15H11BrClNO2S |
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| MW: | 384.7 |
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| CAS: | 388604-55-5 |
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| Purity: | ≥95% |
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| Appearance: | Yellowish solid. |
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| Solubility: | Soluble in DMSO (>5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of two classes of small molecule inhibitors of Arp2/3 complex: B.J. Nolen, et al.; Nature
460, 1031 (2009),
Abstract;
General Literature References
Arp2 links autophagic machinery with the actin cytoskeleton: I. Monastyrska, et al.; Mol. Biol. Cell
19, 1962 (2008),
Abstract;
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