Tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Also shown to inhibit the transmembrane receptor kit and platelet-derived growth factor (PDGF) receptors.
Product Details
| Alternative Name: | STI-571, CGP-57148B |
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| Formula: | C29H31N7O . CH3SO3H |
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| MW: | 493.6 . 96.1 |
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| CAS: | 220127-57-1 |
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| MI: | 14: 4902 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to pale yellow crystalline powder. |
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| Solubility: | Soluble in water (200mg/ml) or DMSO (100mg/ml) or DMF (10mg/ml) or PBS (2mg/ml). Sparingly soluble in ethanol (0.2mg/ml). Storing aqueous solutions for more than one day is not recommended. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17- prostacyclin signalling axis: A.J. Ainscough, et al.; Commun. Biol.
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Combination of PKCδ Inhibition with Conventional TKI Treatment to Target CML Models: F. Muselli, et al.; Cancers
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Full Text
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma: I. Berestjuk, et al.; EMBO Mol. Med. e11814 (2021),
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Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials: C.J. Korbee, et al.; Nat. Commun.
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Full Text
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol.
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Importance of pulmonary vein preferential fibrosis for atrial fibrillation promotion in hypertensive rat hearts: Y. Iwasaki, et al.; Can. J. Cardiol.
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Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR beta signalling: M.T. Weigel, et al.; Cancer Lett.
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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors: E. Buchdunger, et al.; J. Pharmacol. Exp. Ther.
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Abstract;
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative: E. Buchdunger, et al.; Cancer Res.
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