Thienylnaphthamide compound. Potent inhibitor of JNK2 (pIC50=6.5) and JNK3 (pIC50=6.7) targeting the ATP-binding site. Has no activity against JNK1.
Product Details
| Formula: | C20H16N2OS . H2O |
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| MW: | 332.4 . 18.0 |
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| CAS: | 312917-14-9 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Tan solid. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solutions are stable for up to 6 months when stored at -20°C. |
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| Handling: | Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3: R.M. Angell, et al.; Bioorg. Med. Chem. Lett.
17, 1296 (2007),
Abstract;
