Potent quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 (IC50=7nM) over PARP-1 (IC50=33nM). Brain-permeant. Exhibits good pharmacokinetics.
Product Details
| Formula: | C15H10ClN3O |
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| MW: | 283.7 |
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| CAS: | 489457-67-2 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Light brown solid. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling: J. Ishida, et al.; Bioorg. Med. Chem.
14, 1378 (2006),
Abstract;
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors: A. Iwashita, et al.; FEBS Lett.
579, 1389 (2005),
Abstract;
