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AGK2

SIRT2 inhibitor
 
ALX-270-484-M001 1 mg 60.00 USD
 
ALX-270-484-M005 5 mg 175.00 USD
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Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.

Product Details

Alternative Name:2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
 
Formula:C23H13Cl2N3O2
 
MW:434.3
 
CAS:304896-28-4
 
Purity:≥95%
 
Identity:Determined by MS and 1H-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (>5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
270-484
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Product Literature References

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease: T.F. Outeiro, et al.; Science 317, 516 (2007), Abstract;

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