Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Details
| Alternative Name: | 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide |
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| Formula: | C23H13Cl2N3O2 |
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| MW: | 434.3 |
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| CAS: | 304896-28-4 |
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| Purity: | ≥95% |
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| Identity: | Determined by MS and 1H-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease: T.F. Outeiro, et al.; Science
317, 516 (2007),
Abstract;
