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STAT3 inhibitor. Bax activator.
ALX-270-483-M001 1 mg 278.00 USD
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Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.

Product Details

Alternative Name:3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
Identity:Identity determined by MS, 1H- and 13C-NMR.
Appearance:Yellow solid.
Solubility:Soluble in DMSO (>5mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene 26, 2435 (2007), Abstract;
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res. 67, 9630 (2007), Abstract;