Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.
Product Details
| Alternative Name: | 3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide |
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| Formula: | C17H14BrN3O |
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| MW: | 356.2 |
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| CAS: | 857064-38-1 |
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| Purity: | ≥95% |
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| Identity: | Identity determined by MS, 1H- and 13C-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene
26, 2435 (2007),
Abstract;
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res.
67, 9630 (2007),
Abstract;
