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GLI inhibitor
ALX-270-482-M001 1 mg 75.00 USD
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Inhibitor of Hedgehog (Hh) signalling pathway. Blocks the GLI function which constitutes the final step in the Hh pathway. Interferes with GLI1 DNA binding in living cells. Inhibits cell proliferation of tumor cells in vitro in a GLI-dependent manner. Blocks cell growth in an in vivo xenograft model using human prostate cancer cells.

Product Details

Alternative Name:NSC 136476, 2,2’-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl]-benzenamine
Purity:≥95% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (5mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Hygroscopic.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy: A. Citarella, et al.; Cancers 15, 1471 (2023), Abstract;
Hedgehog-GLI signaling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells: A. Po, et al.; Sci. Rep. 10, 13988 (2020), Abstract; Full Text
Tenascin-C predicts poor outcomes for patients with colorectal cancer and drives cancer stemness via Hedgehog signaling pathway: Z. Yang, et al.; Cancer Cell Int. 20, 122 (2020), Abstract; Full Text
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth: L. Lospinoso Severini, et al.; Cancers (Basel) 11, 1518 (2019), Abstract;
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma: A. Po, et al.; Oncogene 36, 4641 (2017), Application(s): Cell Viability Assay w. A549, H1437, and H1734 cells, Abstract; Full Text
Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination: J. Samanta, et al.; Nature 528, 448 (2015), Application(s): Mice cell culture, Abstract;
p,p’-Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways: L. Song, et al. ; Toxicol. Res. 4, 1214 (2015), Application(s): Cell culture,
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 5904 (2011), Abstract; Full Text
Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells: I. Barsoum & H.H. Yao; Biol. Reprod. 84, 894 (2011), Abstract; Full Text
Role of GLI2 in the growth of human osteosarcoma: H. Nagao, et al.; J. Pathol. 224, 169 (2011), Abstract;
Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway: N. Mahindroo, et al.; Bioorg. Med. Chem. 18, 4801 (2010), Abstract; Full Text
cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells: T. Shi, et al.; PLoS One 5, e13054 (2010), Abstract; Full Text
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade: J.M. Hyman, et al.; PNAS USA 106, 14132 (2009), Abstract; Full Text
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007), Abstract; Full Text

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