Nonsteroidal antiandrogen. Effective in the treatment of prostate cancer. Induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 action.
Product Details
| Alternative Name: | N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide |
| |
| Formula: | C18H14F4N2O4S |
| |
| MW: | 430.4 |
| |
| Source: | Synthetic. |
| |
| CAS: | 90357-06-5 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | White crystalline powder. |
| |
| Solubility: | Soluble in acetone and tetrahydrofuran; slightly soluble in 100% ethanol or methanol; practically insoluble in water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy: Y.A. Lin, et al.; Sci. Rep.
11, 10790 (2021),
Abstract;
Full Text
Modeling and prediction of drug dispersability in polyvinylpyrrolidone-vinyl acetate copolymer using a molecular descriptor: K. DeBoyace, et al.; J. Pharm. Sci.
107, 334 (2018),
Abstract;
In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case-control study: J. Rivero, et al. ; Sci. Total Environ.
537, 197 (2015),
Application(s): Cell culture,
Abstract;
Interplay of nuclear factor-kappaB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor alpha: S. Ko, et al.; Mol. Endocrinol.
22, 273 (2008),
Abstract;
A novel class of pyranocoumarin anti-androgen receptor signaling compounds: J. Guo, et al.; Mol. Cancer Ther.
6, 907 (2007),
Abstract;
Full Text
Androgen receptor structural and functional elements: role and regulation in prostate cancer: S.M. Dehm & D.J. Tindall; Mol. Endocrinol.
21, 2855 (2007), (Review),
Abstract;
Increased resistance to trail-induced apoptosis in prostate cancer cells selected in the presence of bicalutamide: M. Mitterberger, et al.; Prostate
67, 1194 (2007),
Abstract;
Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains: B. Cinar, et al.; J. Biol. Chem.
282, 29584 (2007),
Abstract;
Full Text
Androgen receptor corepressors and prostate cancer: C.J. Burd, et al.; Endocr. Relat. Cancer
13, 979 (2006), (Review),
Abstract;
Full Text
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak: C. Castilla, et al.; Endocrinology
147, 4960 (2006),
Abstract;
Full Text
Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells: S. Srinivasan, et al.; Cancer Res.
67, 246 (2006),
Abstract;
Full Text
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies: M. Mimeault & S.K. Batra; Carcinogenesis
27, 1 (2006), (Review),
Abstract;
Full Text
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2’-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer: K.N. Chi, et al.; J. Natl. Cancer Inst.
97, 1287 (2005),
Abstract;
Full Text
Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation: P.M. Ghosh, et al.; Endocr. Relat. Cancer
12, 119 (2005),
Abstract;
Full Text
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers: K.M. Rau, et al.; Endocr. Relat. Cancer
12, 511 (2005), (Review),
Abstract;
Full Text
Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer: X. Liao, et al.; Endocrinology
145, 2941 (2004),
Abstract;
Full Text
Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B: P.K. Vayalil, et al.; Carcinogenesis
25, 987 (2004),
Abstract;
Full Text
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells: M. Verras, et al.; Cancer Res.
64, 8860 (2004),
Abstract;
Full Text
Antiandrogen-induced cell death in LNCaP human prostate cancer cells: E.C. Lee, et al.; Cell Death Differ.
10, 761 (2003),
Abstract;
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours: A. Maucher & E. von Angerer; J. Cancer Res. Clin. Oncol.
119, 669 (1993),
Abstract;
