Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.
Product Details
| Alternative Name: | 5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione |
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| Formula: | C14H8FNO4S |
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| MW: | 305.3 |
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| CAS: | 900515-16-4 |
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| Purity: | ≥98% (1H-NMR) |
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| Appearance: | Yellow-green to brownish solid. |
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| Solubility: | Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 2 years after receip when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta
1853, 1879 (2015),
Application(s): Cell Culture,
Abstract;
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma: V. Pomel, et al.; J. Med. Chem.
49, 3857 (2006),
Abstract;
Full Text
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood
106, 1432 (2005),
Abstract;
Full Text
