Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Details
| Alternative Name: | 5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione |
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| Formula: | C12H7N3O2S |
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| MW: | 257.3 |
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| CAS: | 648450-29-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Pink to reddish brown solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med.
11, 936 (2005),
Abstract;
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus: D.F. Barber, et al.; Nat. Med.
11, 933 (2005),
Abstract;
