Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=650nM) by binding to the mitotic kinesin Eg5.
Product Specification
| Alternative Name: | (5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-β-carboline-1,3-dione |
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| Formula: | C26H21N3O3 |
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| MW: | 423.5 |
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| CAS: | 869304-55-2 |
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| Purity: | ≥95% |
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| Identity: | Identity determined by MS, 1H- and 13C-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months when stored at -20°C in the dark. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem.
13, 6094 (2005),
Abstract;
