Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=650nM) by binding to the mitotic kinesin Eg5.
Product Details
Alternative Name: | (5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-β-carboline-1,3-dione |
|
Formula: | C26H21N3O3 |
|
MW: | 423.5 |
|
CAS: | 869304-55-2 |
|
Purity: | ≥95% |
|
Identity: | Identity determined by MS, 1H- and 13C-NMR. |
|
Appearance: | Yellow solid. |
|
Solubility: | Soluble in DMSO (10mg/ml). |
|
Shipping: | Ambient |
|
Long Term Storage: | -20°C |
|
Use/Stability: | Stable for at least 6 months when stored at -20°C in the dark. |
|
Handling: | Protect from light. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem.
13, 6094 (2005),
Abstract;