Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=200nM) by binding to the mitotic kinesin Eg5.
Product Details
| Alternative Name: | 7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione |
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| Formula: | C16H18N2O2S |
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| MW: | 302.4 |
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| CAS: | 863774-58-7 |
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| Purity: | ≥95% |
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| Identity: | Determined by MS, 1H- and 13C-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) or methanol (5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months when stored at -20°C in the dark. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells: C. Muller, et al.; Cancer Chemother. Pharmacol.
59, 157 (2007),
Abstract;
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5: M. Gartner, et al.; ChemBioChem.
6, 1173 (2005),
Abstract;
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem.
13, 6094 (2005),
Abstract;
