Cell permeable antagonist of the Smoothened (Smo) protein function. Inhibitor of SAG (Prod. No. ALX-270-426) activity. Chemical tool to study the Hedgehog (Hh) signalling pathway and to explore therapeutic uses for inhibitors of Smo.
Product Details
| Alternative Name: | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide |
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| Formula: | C26H26ClN3O4 |
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| MW: | 480.0 |
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| CAS: | 329196-48-7 |
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| Purity: | ≥95% |
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| Identity: | Identity determined by MS, 1H- and 13C-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months when stored at -20°C in the dark. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS
99, 14071 (2002),
Abstract;
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