Analog of kenpaullone (Prod. No. BML-EI310) acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on GSK-3β than over CDK1/cyclin B and CDK5/p25 (IC50=2.0µM and 4.2µM, respectively).
Product Details
| Alternative Name: | 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 1-AKP |
| |
| Formula: | C15H10BrN3O |
| |
| MW: | 328.2 |
| |
| CAS: | 676596-65-9 |
| |
| Purity: | ≥95% (HPLC, TLC) |
| |
| Appearance: | Off-white to brown powder. |
| |
| Solubility: | Soluble in DMSO; insoluble in water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stock solutions are stable for up to 6 months when stored at -20°C. |
| |
| Handling: | Protect from moisture. Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta: T. Hirota, et al.; PNAS USA
105, 20746 (2008),
Abstract;
Full Text
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lett.
15, 823 (2005),
Abstract;
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett.
14, 413 (2004),
Abstract;
Related Products
