Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. BML-CC104)).
Product Details
| Formula: | C21H17Cl3N4OS |
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| MW: | 479.8 |
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| CAS: | 405060-95-9 |
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| Purity: | ≥98% (HPLC(UV)) |
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| Identity: | Determined by MS, 1H-NMR and 13C-NMR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
3,3’-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells: A.A. Goldberg, et al.; Genes Cancer
6, 265 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Early endosomes and endosomal coatomer are required for autophagy: M. Razi, et al.; J. Cell Biol.
185, 305 (2009),
Abstract;
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ.
15, 589 (2008),
Abstract;
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science
307, 935 (2005),
Abstract;
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