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ALX-270-428-M001 1 mg 42.00 USD
ALX-270-428-M005 5 mg 128.00 USD
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Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. BML-CC104)).

Product Details

Purity:≥98% (HPLC(UV))
Identity:Determined by MS, 1H-NMR and 13C-NMR.
Appearance:White to off-white powder.
Solubility:Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml).
Long Term Storage:-20°C
Use/Stability:Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

3,3’-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells: A.A. Goldberg, et al.; Genes Cancer 6, 265 (2015), Application(s): Cell Culture, Abstract; Full Text
Early endosomes and endosomal coatomer are required for autophagy: M. Razi, et al.; J. Cell Biol. 185, 305 (2009), Abstract;
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008), Abstract;
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005), Abstract;

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