A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Product Details
Formula: | C28H28ClN3OS |
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MW: | 490.1 |
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CAS: | 912545-86-9 |
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Purity: | ≥95% (HPLC) |
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Identity: | Determined by MS and NMR. |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility). |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 6 months when stored at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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