Gallotannin

Inhibitor of PARG and eNOS



ALX-270-418-G001	1 g	45.00 USD
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Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.

Product Details

Alternative Name:	Tannic acid

Formula:	C₇₆H₅₂O₄₆

MW:	1701.2

Source:	Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.

CAS:	1401-55-4

MI:	14: 9052

RTECS:	WW5075000

Purity:	≥95%

Appearance:	Beige to light brown powder.

Solubility:	Soluble in water, 100% ethanol, acetone or warm glycerol.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Diadenosine 5′, 5′′′-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication: A.S. Marriott, et al.; DNA Repair (Amst.) 33, 90 (2015), Application(s): Cell Culture, Abstract;

The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007), Abstract;

Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006), Abstract;

Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005), Abstract;

Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004), Abstract;

Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000), Abstract;

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000), Abstract;

Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995), Abstract;