Cell permeable, highly potent inhibitor of γ-secretase (IC50=0.06nM).
Product Details
| Formula: | C31H24F3N3O3 |
| |
| MW: | 543.5 |
| |
| Purity: | ≥98% |
| |
| Appearance: | White to off-white solid. |
| |
| Solubility: | Soluble in DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. Hygroscopic. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of a: I. Churcher, et al.; J. Med. Chem.
46, 2275 (2003),
Abstract;
