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Compound 34

γ-Secretase inhibitor
ALX-270-417-C200 200 µg 112.00 USD
ALX-270-417-M001 1 mg 307.00 USD
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Cell permeable, highly potent inhibitor of γ-secretase (IC50=0.06nM).

Product Details

Appearance:White to off-white solid.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Hygroscopic.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of a: I. Churcher, et al.; J. Med. Chem. 46, 2275 (2003), Abstract;

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