Competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).
Product Details
| Alternative Name: | NOG |
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| Formula: | C4H5NO5 |
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| MW: | 147.1 |
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| CAS: | 5262-39-5 |
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| Purity: | ≥98% (1H-NMR) |
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| Identity: | Determined by 1H-NMR and 13C-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structural basis for human PHF2 Jumonji domain interaction with metal ions: J.R. Horton, et al.; J. Mol. Biol.
406, 1 (2011),
Abstract;
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases: J.R. Horton, et al.; Nat. Struct. Mol. Biol.
17, 38 (2010),
Abstract;
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives: C.J. Cunliffe, et al.; J. Med. Chem.
35, 2652 (1992),
Abstract;
