Specific inhibitor of CDK2/cyclin A (IC50=500nM) and CDK2/cyclin E (IC50=500nM). Also inhibits CDK1/cyclin B (IC50=4.2µM) and CDK4/cyclin D1 (IC50=215µM).
Product Details
| Alternative Name: | 6-(4-Methoxybenzylamino)-2-[bis(2-hydroxyethylamino)]-9-isopropylpurine |
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| Formula: | C20H28N6O3 |
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| MW: | 400.5 |
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| CAS: | 199986-75-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in DMSO, dimethyl formamide or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling: R.N. Bhattacharjee, et al.; Mol. Cell. Biol.
21, 5417 (2001),
Abstract;
Full Text
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation: E.E. Brooks, et al.; J. Biol. Chem.
272, 29207 (1997),
Abstract;
Full Text
