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CGP 74514A

CDK/cyclin inhibitor
ALX-270-391-M005 5 mg 107.00 USD
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Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC50=25nM). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC50=6.1µM), PKA (IC50=125µM) and EGFR (IC50>10µM). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3µM).

Product Details

Alternative Name:N-(cis-2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine
Purity:≥95% (HPLC)
Appearance:White to yellow solid.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Packaged under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process: C. Yu, et al.; Cancer Res. 63, 1822 (2003), Abstract;
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors: P. Imbach, et al.; Bioorg. Med. Chem. Lett. 9, 91 (1999), Abstract;