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Anacardic acid



ALX-270-381-M005	5 mg	67.00 USD

ALX-270-381-M025	25 mg	275.00 USD
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Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC₅₀~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.Inhibits SUMOylation of RanGAP1-C2 with an IC₅₀ = 2.2µM

Product Details

Alternative Name:	2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA

Formula:	C₂₂H₃₆O₃

MW:	348.5

Source:	Synthetic.

CAS:	16611-84-0

MI:	14: 621

Purity:	≥95% (HPLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.

Shipping:	Ambient

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 3 months when stored at -20°C.

Handling:	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Rab17 Regulates apical delivery of hepatic transcytotic vesicles: A.C. Striz, et al.; Mol. Biol. Cell. 29, 2887 (2018), Abstract; Full Text

Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein: T. Nabekura, et al.; Biomed. Pharmacother. 70, 140 (2015), Application(s): Cell Culture, Abstract;

The inhibitory effects of anacardic acid on hepatitis C virus life cycle: J. Hundt, et al.; PLoS One 10, e0117514 (2015), Application(s): Assay, Cell Culture, Abstract; Full Text

Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. & Biol. 16, 133 (2009), Abstract;

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett. 580, 4353 (2006), Abstract;

Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003), Abstract; Full Text

Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol. 80, 387 (1996), Abstract;

Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids: R. Grazzini, et al.; BBRC 176, 775 (1991), Abstract;

Anacardic Acid: molluscicide in cashew nut shell liquid: J.T. Sullivan, et al.; Planta Med. 44, 175 (1982), Abstract;

General Literature References

Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition: R. Paramashivappa, et al.; J. Agric. Food Chem. 50, 7709 (2002), Abstract;

Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi and I. Kubo; J. Appl. Bacteriol. 80, 387 (1996), Abstract;