Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC50~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.Inhibits SUMOylation of RanGAP1-C2 with an IC50 = 2.2µM
Product Details
| Alternative Name: | 2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA |
| |
| Formula: | C22H36O3 |
| |
| MW: | 348.5 |
| |
| Source: | Synthetic. |
| |
| CAS: | 16611-84-0 |
| |
| MI: | 14: 621 |
| |
| Purity: | ≥95% (HPLC) |
| |
| Appearance: | White to off-white solid. |
| |
| Solubility: | Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
| |
| Handling: | Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS: D. Hatakeyama, et al.; FASEB J.
36, e22593 (2022),
Abstract;
Rab17 Regulates apical delivery of hepatic transcytotic vesicles: A.C. Striz, et al.; Mol. Biol. Cell.
29, 2887 (2018),
Abstract;
Full Text
Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein: T. Nabekura, et al.; Biomed. Pharmacother.
70, 140 (2015),
Application(s): Cell Culture,
Abstract;
The inhibitory effects of anacardic acid on hepatitis C virus life cycle: J. Hundt, et al.; PLoS One
10, e0117514 (2015),
Application(s): Assay, Cell Culture,
Abstract;
Full Text
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. & Biol.
16, 133 (2009),
Abstract;
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett.
580, 4353 (2006),
Abstract;
Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem.
278, 19134 (2003),
Abstract;
Full Text
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol.
80, 387 (1996),
Abstract;
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids: R. Grazzini, et al.; BBRC
176, 775 (1991),
Abstract;
Anacardic Acid: molluscicide in cashew nut shell liquid: J.T. Sullivan, et al.; Planta Med.
44, 175 (1982),
Abstract;
General Literature References
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition: R. Paramashivappa, et al.; J. Agric. Food Chem.
50, 7709 (2002),
Abstract;
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi and I. Kubo; J. Appl. Bacteriol.
80, 387 (1996),
Abstract;
