Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC50~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.Inhibits SUMOylation of RanGAP1-C2 with an IC50 = 2.2µM
Product Details
Alternative Name: | 2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA |
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Formula: | C22H36O3 |
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MW: | 348.5 |
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Source: | Synthetic. |
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CAS: | 16611-84-0 |
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MI: | 14: 621 |
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Purity: | ≥95% (HPLC) |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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Handling: | Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. & Biol.
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Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem.
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Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol.
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General Literature References
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Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi and I. Kubo; J. Appl. Bacteriol.
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