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PPARγ activator
ALX-270-367-M001 1 mg 67.00 USD
ALX-270-367-M005 5 mg 161.00 USD
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Pioglitazone selectively activates PPARγ-1. It is about one tenth as potent as rosiglitazone (EC50~500nM for human and mouse PPARγ). In a transactivation assay using COS-1 cells transfected with full length human PPARα and RXRα, pioglitazone and rosiglitazone exhibit low level activation of PPARα at 1µM and 5.4- and 4.2-fold activation, respectively, at a concentration of 10µM.

Product Details

MI:14: 7452
Purity:≥97% (HPLC)
Identity:Confirmed by 1H-NMR
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (2.5mg/ml) or dimethyl formamide (2.5mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from moisture.
Scientific Background:Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (Prod. No. ALX-350-125) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Endoplasmic reticulum stress increases LECT2 expression via ATF4: C.Y. Park, et al.; Biochem. Biophys. Res. Commun. 585, 169 (2021), Abstract;
Cigarette Smoke Extract Modulates Functions of Peroxisome Proliferator-Activated Receptors: M. Matsushita, et al.; Biol. Pharm. Bull. 42, 1628 (2019), Abstract; Full Text
Effect of zinc supplements in the attenuated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart: S.K. Kansal, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 388, 635 (2016), Application(s): Cell culture, Abstract; Full Text
Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells: D. Gao, et al.; PLoS One 10, e0123724 (2015), Application(s): Cell Culture, Abstract; Full Text
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone: J. Sakamoto, et al.; BBRC 278, 704 (2000), Abstract;
The PPARs: from orphan receptors to drug discovery: T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000), Abstract;
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996), Abstract;
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995), Abstract; Full Text
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994), Abstract;

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