Pioglitazone selectively activates PPARγ-1. It is about one tenth as potent as rosiglitazone (EC50~500nM for human and mouse PPARγ). In a transactivation assay using COS-1 cells transfected with full length human PPARα and RXRα, pioglitazone and rosiglitazone exhibit low level activation of PPARα at 1µM and 5.4- and 4.2-fold activation, respectively, at a concentration of 10µM.
Product Details
| Formula: | C19H20N2O3S |
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| MW: | 356.4 |
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| CAS: | 111025-46-8 |
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| MI: | 14: 7452 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Confirmed by 1H-NMR |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (2.5mg/ml) or dimethyl formamide (2.5mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Scientific Background: | Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (Prod. No. ALX-350-125) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands. |
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| Regulatory Status: | RUO - Research Use Only |
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