Non-selective inhibitor of receptor tyrosine kinases (RTKs). Inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC50 ~5-25µM). Consists primarily of the E-isomer; contains ~5% of the Z-isomer.
Product Details
| Formula: | C18H17NO |
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| MW: | 263.4 |
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| Source: | Synthetic. |
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| CAS: | 186611-55-2 |
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| Purity: | ≥98% (1H-NMR, HPLC) |
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| Identity: | Determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV. |
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| Appearance: | Yellow crystals. |
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| Solubility: | Soluble in DMSO (>80mg/ml) or methanol (8mg/ml); sparingly soluble in aqueous buffers (25µg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month. |
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| Handling: | Protect from light. Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem.
41, 2588 (1998),
Abstract;
