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Receptor tyrosine kinase (RTK) inhibitor
ALX-270-362-M001 1 mg 72.00 USD
ALX-270-362-M005 5 mg 276.00 USD
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Non-selective inhibitor of receptor tyrosine kinases (RTKs). Inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC50 ~5-25µM). Consists primarily of the E-isomer; contains ~5% of the Z-isomer.

Product Details

Purity:≥98% (1H-NMR, HPLC)
Identity:Determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.
Appearance:Yellow crystals.
Solubility:Soluble in DMSO (>80mg/ml) or methanol (8mg/ml); sparingly soluble in aqueous buffers (25µg/ml).
Long Term Storage:+4°C
Use/Stability:Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
Handling:Protect from light. Keep cool and dry.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998), Abstract;