Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.
Product Specification
| Alternative Name: | D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate] |
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| Formula: | C28H57O9P |
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| MW: | 568.7 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR, 31P-NMR, and LC-MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LDOC1 Suppresses Microbe-Induced Production of IL-1β in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3β Axis: C. Lee, et al.; Cancers (Basel)
12, 3148 (2020),
Abstract;
Full Text
Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K–Akt pathway: K. Kucharava, et al.; Sci. Rep.
10, 110 (2019),
Application(s): WB- Canine Cochlea Cells,
Abstract;
Full Text
Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin: M. Ashry, et al.; Reprod. Biol. Endocrinol.
16, 1 (2018),
Abstract;
Full Text
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS
125, 1144 (2003),
Abstract;
