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Akt inhibitor
ALX-270-350-MC05 0.5 mg 185.00 USD
ALX-270-350-M001 1 mg 329.00 USD
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Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

Product Specification

Alternative Name:D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR, 31P-NMR, and LC-MS.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.
Long Term Storage:-20°C
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

LDOC1 Suppresses Microbe-Induced Production of IL-1β in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3β Axis: C. Lee, et al.; Cancers (Basel) 12, 3148 (2020), Abstract; Full Text
Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K–Akt pathway: K. Kucharava, et al.; Sci. Rep. 10, 110 (2019), Application(s): WB- Canine Cochlea Cells, Abstract; Full Text
Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin: M. Ashry, et al.; Reprod. Biol. Endocrinol. 16, 1 (2018), Abstract; Full Text
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003), Abstract;

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