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Akt inhibitor
ALX-270-349-MC05 0.5 mg 204.00 USD
ALX-270-349-M001 1 mg 347.00 USD
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Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

Product Details

Alternative Name:D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR, 31P-NMR, 13C-NMR and MS.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract;
Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia: B. Zhu, et al.; Int. J. Clin. Exp. Pathol. 8, 12595 (2015), Application(s): Cell culture, Abstract; Full Text
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators: X. Sun, et al.; Cell Cycle 14, 721 (2015), Abstract; Full Text
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003), Abstract;

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