Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.
Product Details
| Alternative Name: | D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate] |
| |
| Formula: | C29H59O10P |
| |
| MW: | 598.7 |
| |
| Purity: | ≥98% (TLC) |
| |
| Identity: | Determined by 1H-NMR, 31P-NMR, 13C-NMR and MS. |
| |
| Appearance: | White to off-white solid. |
| |
| Solubility: | Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | +4°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev.
2021, 5521196 (2021),
Abstract;
Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia: B. Zhu, et al.; Int. J. Clin. Exp. Pathol.
8, 12595 (2015),
Application(s): Cell culture,
Abstract;
Full Text
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators: X. Sun, et al.; Cell Cycle
14, 721 (2015),
Abstract;
Full Text
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS
125, 1144 (2003),
Abstract;
