Slow-binding competitive inhibitor of arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation.
Product Details
| Alternative Name: | S-(2-Boronoethyl)-L-cysteine . NH4 |
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| Formula: | C5H11BNO4S . NH4 |
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| MW: | 192.0 . 18.0 |
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| CAS: | 63107-40-4 (non-salt) |
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| Purity: | ≥95% (TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Very hygroscopic. Keep under inert gas. Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation: J. A. Scott, et al.; J. Appl. Physiol. (1985)
118, 1229 (2015),
Application(s): Intratracheal Instillation ,
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Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin: L.A. Holowatz, et al.; Am. J. Physiol. Heart Circ. Physiol.
291, H2965 (2006),
Abstract;
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism: J. Steppan, et al.; PNAS
103, 4759 (2006),
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Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium: A.S. Jung, et al.; Am. J. Physiol. Heart Circ. Physiol.
290, H1756 (2006),
Abstract;
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS
102, 13058 (2005),
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Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels: D.E. Berkowitz, et al.; Circulation
108, 2000 (2003),
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Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori & D.E. Ash; Biochemistry
40, 9356 (2001),
Abstract;
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation: L.H. Wei, et al.; PNAS
98, 9260 (2001),
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Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase: J.D. Cox, et al.; Biochemistry
40, 2689 (2001),
Abstract;
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum: N.N. Kim, et al.; Biochemistry
40, 2678 (2001),
Abstract;
