Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
Product Details
| Alternative Name: | 3-OMe-GlcNAc |
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| Formula: | C9H17NO6 |
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| MW: | 235.2 |
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| CAS: | 94825-74-8 |
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| Purity: | ≥98% (1H-NMR) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (10mg/ml) or water (10mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver: I. Miwa, et al.; Enzyme Protein
48, 135 (1994),
Abstract;
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro: R. Zeitler, et al.; Eur. J. Biochem.
204, 1165 (1992),
Abstract;
