Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC50=1µM).
Product Details
| Alternative Name: | 3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one |
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| Formula: | C21H18N2O |
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| MW: | 314.4 |
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| CAS: | 163655-37-6 |
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| Purity: | ≥98% |
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| Identity: | Identity determined by MS, 1H- and 13C-NMR. |
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| Appearance: | Orange crystals. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression: A.R. Harris, et al.; BMC Cancer
18, 718 (2018),
Abstract;
Full Text
Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells: C.I. Lin, et al.; Cell. Mol. Life Sci.
65, 2740 (2008),
Application(s): tube formation and lymphatic marker expression studies on HUVECs,
Abstract;
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo: V. Kirkin, et al.; Int. J. Cancer
112, 986 (2004),
Application(s): proliferation assays in vivo and on primary human and tumor cell lines,
Abstract;
Full Text
Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2: V. Kirkin, et al.; Eur. J. Biochem.
268, 5530 (2001),
Abstract;
