Potent Raf1 kinase inhibitor (IC50=9nM). Shows ≥100-fold selectivity for Raf kinase versus CDK1, CDK2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.
Product Details
| Alternative Name: | 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074 |
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| Formula: | C15H8Br2INO2 |
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| MW: | 520.9 |
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| CAS: | 220904-83-6 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Off-white to orange powder. |
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| Solubility: | Soluble in DMSO (200mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for at least 6 months when stored at -20°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The discovery of potent cRaf1 kinase inhibitors: K. Lackey, et al.; Bioorg. Med. Chem. Lett.
10, 223 (2000),
Abstract;
