Potent, cell permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50=700pM). Antitumor agent in vivo.
Product Specification
| Alternative Name: | 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline |
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| Formula: | C17H13BrN4O |
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| MW: | 369.2 |
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| CAS: | 194423-15-9 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow to orange solid. |
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| Solubility: | Soluble in DMSO (200 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep under inert gas. |
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Product Literature References
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor: D.W. Fry, et al.; PNAS
95, 12022 (1998),
Abstract;
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