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Formononetin (high purity)

IL-4 activator
ALX-270-312-M005 5 mg 201.00 USD
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Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.

Product Details

Alternative Name:7-Hydroxy-4’-methoxyisoflavone (high purity), 7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
MI:14: 4244
Purity:≥97% (HPLC, TLC)
Appearance:White to greyish powder.
Solubility:Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
Long Term Storage:+4°C
Use/Stability:Place in a desiccator under vacuum for 48 hours before use.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005), Abstract;
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004), Abstract;
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000), Abstract;
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999), Abstract;
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997), Abstract;
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995), Abstract;
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995), Abstract;
Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994), Abstract;

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