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Formononetin (high purity)

IL-4 activator



ALX-270-312-M005	5 mg	226.00 USD
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Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.

Product Details

Alternative Name:	7-Hydroxy-4’-methoxyisoflavone (high purity), 7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)

Formula:	C₁₆H₁₂O₄

MW:	268.3

CAS:	485-72-3

MI:	14: 4244

Purity:	≥97% (HPLC, TLC)

Appearance:	White to greyish powder.

Solubility:	Soluble in DMSO (200mg/ml) or methanol (2mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Use/Stability:	Place in a desiccator under vacuum for 48 hours before use.

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005), Abstract;

Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004), Abstract;

Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000), Abstract;

Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999), Abstract;

Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997), Abstract;

Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995), Abstract;

Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995), Abstract;

Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994), Abstract;