Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM; hSIRT1: IC50=60µM; hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC50=70µM) and hSIRT2 (IC50=40µM) in vitro.
Product Details
| Alternative Name: | Sir Two Inhibitor Naphthol, 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide |
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| Formula: | C26H22N2O2 |
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| MW: | 394.5 |
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| CAS: | 410536-97-9 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | NMR |
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| Appearance: | Off-white to yellow crystals. |
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| Solubility: | Soluble in DMSO, 100% ethanol or dimethyl formamide. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Relatively unstable in aqueous solution, especially at acidic pH. |
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| Handling: | Protect from moisture. Protect from light. Store under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem.
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