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Sirtinol

SIRT inhibitor
 
ALX-270-308-M001 1 mg 41.00 USD
 
ALX-270-308-M005 5 mg 132.00 USD
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Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM; hSIRT1: IC50=60µM; hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC50=70µM) and hSIRT2 (IC50=40µM) in vitro.

Product Details

Alternative Name:Sir Two Inhibitor Naphthol, 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
 
Formula:C26H22N2O2
 
MW:394.5
 
CAS:410536-97-9
 
Purity:≥97% (HPLC)
 
Identity:NMR
 
Appearance:Off-white to yellow crystals.
 
Solubility:Soluble in DMSO, 100% ethanol or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Relatively unstable in aqueous solution, especially at acidic pH.
 
Handling:Protect from moisture. Protect from light. Store under inert gas.
 
Regulatory Status:RUO - Research Use Only
 
270-308
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Product Literature References

Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies: K. Nakai, et al.; Am. J. Pathol. 181, 969 (2012), Abstract;
Identification and characterization of novel sirtuin inhibitor scaffolds: B.D. Sanders, et al.; Bioorg. Med. Chem. 17, 7031 (2009), Abstract;
SIRT1 regulation of apoptosis of human chondrocytes: K. Takayama, et al.; Arthritis Rheum. 60, 2731 (2009), Abstract; Full Text
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006), Abstract;
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005), Abstract;
Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases: B. Heltweg, et al.; Anal. Biochem. 319, 42 (2003), Abstract;
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity: C.E. Koering, et al.; EMBO Rep. 3, 1055 (2002), Abstract; Full Text
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001), Abstract; Full Text

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