Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Details
| Alternative Name: | 5-Aminoisoquinolinone . HCl |
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| Formula: | C9H8N2O . HCl |
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| MW: | 160.2 . 36.5 |
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| CAS: | 93117-07-8 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Beige to brown powder. |
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| Solubility: | Soluble in water (warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier: J. Neuroinflammation; S. Rom, et al.
13, 254 (2016),
Application(s): Cell culture with primary human monocytes from HIV-1/hepatitis B seronegative donors ,
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Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis: B.D. Poole, et al.; Int. J. Med. Sci.
8, 88 (2011),
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Oocyte numbers in the mouse increase after treatment with 5-aminoisoquinolinone: a potent inhibitor of poly(ADP-ribosyl)ation: H. Qian, et al.; Biol. Reprod.
82, 1000 (2010),
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Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation: N.R. Jog, et al.; J. Immunol.
182, 7297 (2009),
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Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell
32, 57 (2008),
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Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury: S. Cuzzocrea, et al.; Biochem. Pharmacol.
63, 293 (2002),
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Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol.
130, 843 (2000),
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