Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor.
Product Details
| Alternative Name: | DFMO . HCl . H2O, Eflornithine . HCl . H2O, RMI-71782 |
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| Formula: | C6H12F2N2O2 . HCl . H2O |
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| MW: | 236.6 |
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| CAS: | 96020-91-6 |
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| MI: | 14: 3522 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme: Z. Urban-Wójciuk, et al.; Cancer Gene Ther.
10, 1038 (2021),
Abstract;
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model: Y. Takahashi, et al.; Int. J. Cancer
85, 243 (2000),
Abstract;
Development of difluoromethylornithine (DFMO) as a chemoprevention agent: F.L. Meyskens, Jr. & E.W. Gerner; Clin. Cancer Res.
5, 945 (1999), (Review),
Abstract;
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Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells: M. Selamnia, et al.; Biochem. Pharmacol.
55, 1241 (1998),
Abstract;
Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages?: D.M. Morgan; Biochem. Soc. Trans.
22, 389S (1994),
Abstract;
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase: A.K. Verma; Basic Life Sci.
52, 195 (1990), (Review),
Abstract;
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity: M.A. Markwell, et al.; Eur. J. Pharmacol.
182, 607 (1990),
Abstract;
The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-alpha-difluoromethylornithine: a chemopreventive agent: A.K. Verma; Prev. Med.
18, 646 (1989),
Abstract;
The effect of alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on mitogen-induced interleukin 2 production: T.L. Bowlin, et al.; Immunopharmacology
13, 143 (1987),
Abstract;
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine: J.G. Delcros, et al.; FEBS Lett.
171, 221 (1984),
Abstract;
Kinetics of alpha-difluoromethylornithine: an irreversible inhibitor of ornithine decarboxylase: K.D. Haegele, et al.; Clin. Pharmacol. Ther.
30, 210 (1981),
Abstract;
Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase: S. Oredsson, et al.; Acta Chem. Scand. B
34, 457 (1980),
Abstract;
Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice: N.J. Prakash, et al.; Cancer Res.
38, 3059 (1978),
Abstract;
