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Cell permeable vitamin E derivative
ALX-270-267-M100 100 mg 45.00 USD
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Replaces Prod. #: BML-FR105

Cell permeable derivative of vitamin E. Antioxidant. Inhibits peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Prevents lipid peroxidation, cytotoxicity and apoptosis induced by cytochrome P450 2E1 in HEP G2 cells.

Product Details

Alternative Name:6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
CAS:53188-07-1; 56305-04-5
Purity:≥96.5% (Titration (T) NaOH 0.1M)
Identity:Determined by IR.
Appearance:White to off-white, pale yellow or pale green powder.
Solubility:Soluble in 100% ethanol (25mg/ml) or methanol.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Angiopoietins stimulate pancreatic islet development from stem cells: S. S. Karanth, et al.; Sci. Rep. 11, 13558 (2021), Abstract;
Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance: C.A. Karg, et al.; NPJ Sci. Food 5, 1038 (2021), Abstract;
Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells: S. Konagaya, et al.; Sci. Rep. 9, 640 (2019), Abstract;
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract; Full Text
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells: N.I. Díaz-Valdivia, et al.; Oncotarget 8, 111943 (2017), Abstract; Full Text
Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells: K. Hirano, et al.; Biochem. Biophys. Res. Commun. 487, 344 (2017), Application(s): hiPSC line 253G1, Abstract;
Bactericidal activity of green tea extracts: the importance of catechin containing nano particles: J. Gopal, et al.; Sci. Rep. 6, 19710 (2016), Application(s): Cell culture, Abstract; Full Text
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer: J.L. Roh, et al.; Cancer Lett. 381, 96 (2016), Application(s): Cell viability assays, Abstract;
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells: Q. Chen et al.; Mol. Pharmacol. 53, 638 (1998), Abstract;
Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?: A.S. Pannala et al.; Free Radic Biol Med 24, 594 (1998), Abstract;
Peroxynitrite and brain mitochondria: evidence for increased proton leak: P.S. Brookes et al.; J. Neurochem. 70, 2195 (1998), Abstract;
Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes: M.G. Salgo & W.A. Pryor; Arch. Biochem. Biophys. 333, 482 (1996), Abstract;
Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected]: M.G. Salgo, et al.; Arch. Biochem. Biophys. 322, 500 (1995), Abstract;

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