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Carnosic acid

PPARγ activator. Antioxidant.
ALX-270-264-M010 10 mg 73.00 USD
ALX-270-264-M050 50 mg 215.00 USD
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Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.

Product Details

Source:Isolated from Rosmarinus officinalis.
Purity:≥95% (HPLC)
Appearance:Yellow powder.
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid: S. Pesakhov, et al.; Oncotarget 7, 31847 (2016), Abstract; Full Text
Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa: K. Kang, et al.; Sci. Rep. 6, 22632 (2016), Application(s): Injection into mice, Abstract; Full Text
Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells: S. Nishimoto, et al.; Toxicol. Appl. Pharmacol. 305, 161 (2016), Application(s): Nuclear transcription factor activation, Abstract;
Carnosic acid protects photoreceptor against degeneration in Pde6rd10 mice through activating Nrf2 pathway: K. Kang, et al.; Acta Pharm. Sin. B (2015), Application(s): Intraperitoneal injection to Pde6rd10 mice,
The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity: K. Linnewiel-Hermoni, et al.; Arch. Biochem. Biophys. 572, 28 (2015), Application(s): Cell Culture, Abstract;
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007), Abstract;
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006), Abstract;
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999), Abstract;
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995), Abstract;
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995), Abstract;
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994), Abstract;
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992), Abstract;
Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992), Abstract;

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