Potent, cell permeable and selective inhibitor of p38 (SAPK2a).
Product Details
| Alternative Name: | 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole |
| |
| Formula: | C20H13FN4O2 |
| |
| MW: | 360.3 |
| |
| CAS: | 152121-53-4 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Identity: | Determined by 1H-NMR and MS. |
| |
| Appearance: | Yellow to orange solid. |
| |
| Solubility: | Soluble in DMSO; slightly soluble in methanol. Insoluble in water, ethyl acetate or diethyl ether. |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection: K.P. Kota, et al.; PloS One
8, e55167 (2013),
Application(s): WB, Electron Microscopy,
Abstract;
Full Text
Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint: B. Fox, et al.; J. Cell. Mol. Med.
16, 896 (2012),
Application(s): Flow Cytometry,
Abstract;
Full Text
Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway: B. Bellei, et al.; PloS One
7, e330201 (2012),
Application(s): WB, PCR, Flow, IF,
Abstract;
Full Text
Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways: I. Moserova & J. Kralova; PloS One
7, e32972 (2012),
Application(s): WB, PCR, Flow, IF,
Abstract;
Full Text
Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress: H. Chen, et al.; Mol. Cell. Endocrinol.
323, 147 (2010),
Application(s): WB, Assays,
Abstract;
Full Text
Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells: D. Duval, et al.; Cell Death Differ.
13, 564 (2006),
Application(s): WB, IHC, PCR,
Abstract;
Full Text
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin: Z. Assefa, et al.; J. Biol. Chem.
274, 8788 (1999),
Abstract;
Full Text
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase: J.L. Kummer, et al.; J. Biol. Chem.
272, 20490 (1997),
Abstract;
Full Text
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem.
5, 49 (1997),
Abstract;
