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United States 

PD 169,316

p38 inhibitor
ALX-270-258-M001 1 mg 124.00 USD
ALX-270-258-M050 50 mg 1,611.00 USD
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Potent, cell permeable and selective inhibitor of p38 (SAPK2a).

Product Details

Alternative Name:4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR and MS.
Appearance:Yellow to orange solid.
Solubility:Soluble in DMSO; slightly soluble in methanol. Insoluble in water, ethyl acetate or diethyl ether.
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection: K.P. Kota, et al.; PloS One 8, e55167 (2013), Application(s): WB, Electron Microscopy, Abstract; Full Text
Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint: B. Fox, et al.; J. Cell. Mol. Med. 16, 896 (2012), Application(s): Flow Cytometry, Abstract; Full Text
Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway: B. Bellei, et al.; PloS One 7, e330201 (2012), Application(s): WB, PCR, Flow, IF, Abstract; Full Text
Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways: I. Moserova & J. Kralova; PloS One 7, e32972 (2012), Application(s): WB, PCR, Flow, IF, Abstract; Full Text
Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress: H. Chen, et al.; Mol. Cell. Endocrinol. 323, 147 (2010), Application(s): WB, Assays, Abstract; Full Text
Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells: D. Duval, et al.; Cell Death Differ. 13, 564 (2006), Application(s): WB, IHC, PCR, Abstract; Full Text
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin: Z. Assefa, et al.; J. Biol. Chem. 274, 8788 (1999), Abstract; Full Text
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase: J.L. Kummer, et al.; J. Biol. Chem. 272, 20490 (1997), Abstract; Full Text
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997), Abstract;

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