Replaces Prod. #: BML-EI160
Activates PPARα. Induces cytochrome P450 4A1 and 4A3 which catalize the omega-oxidation of fatty acids and prostaglandins.
Product Details
| Alternative Name: | 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester |
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| Formula: | C12H15ClO3 |
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| MW: | 242.7 |
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| CAS: | 637-07-0 |
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| MI: | 14: 2377 |
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| Purity: | ≥98% (GC) |
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| Appearance: | Colorless oil. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Solutions are stable for up to 6 months when stored at –20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS
89, 4653 (1992),
Abstract;
Effect of clofibrate treatment on hepatic prostaglandin catabolism and action: E.P. Brass & L.J. Ruff; J. Pharmacol. Exp. Ther.
257, 1034 (1991),
Abstract;
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha: T. Aoyama et al.; J. Lipid. Res.
31, 1477 (1990),
Abstract;
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