Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Purvalanol A

CDK/cyclin inhibitor
ALX-270-246-M001 1 mg 79.00 USD
ALX-270-246-M005 5 mg 348.00 USD
Do you need bulk/larger quantities?
Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.

Product Details

Alternative Name:6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
Purity:≥99% (NMR)
Appearance:Off-white to yellow powder.
Solubility:Soluble in DMSO, methanol or dichloromethane.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Keep under inert gas. Keep cool and dry.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One 8, e72886 (2013), Abstract; Full Text
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004), Abstract;
Up-regulation of cdc2 protein during paclitaxel-induced apoptosis: P. Chadebech, et al.; Int. J. Cancer 87, 779 (2000), Abstract;
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science 281, 533 (1998), Abstract;

Related Literature

Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

All new literature pieces