Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


nNOS inhibitor
ALX-270-216-M005 5 mg 111.00 USD
ALX-270-216-M025 25 mg 390.00 USD
Do you need bulk/larger quantities?
Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.

Product Details

Alternative Name:N5-(1-Imino-3-butenyl)-L-ornithine, L-VNIO
Formula:C9H17N3O2 . HCl
Purity:≥95% (TLC)
Appearance:Off-white solid to clear film.
Solubility:Soluble in water, 100% ethanol (30mg/ml), DMSO (50mg/ml) or dimethyl formamide (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Very hygroscopic. Open only in anhydrous atmosphere.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model: T. Dupas, et al.; Oxid. Med. Cell. Longev. 2022, 7377877 (2022), Abstract;
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats: L.M. Yamaleyeva, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R819 (2007), Abstract;
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia: K. Kawahara, et al.; J. Mol. Cell Cardiol. 40, 35 (2006), Abstract;
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries: Y. Hatanaka, et al.; J. Pharmacol. Exp. Ther. 316, 490 (2006), Abstract;
Myocardial effects of nitric oxide, NO. Clinical and experimental evidence: C. Heymes, et al.; Bull. Acad. Natl. Med. 189, 893 (2005), [Article in French], Abstract;
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines: L.E. Bretscher, et al.; J. Biol. Chem. 278, 46789 (2003), Abstract; Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract; Full Text
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase: B. R. Babu & O.W. Griffith; J. Biol. Chem. 273, 8882 (1998), Abstract; Full Text

General Literature References

Design of isoform-selective inhibitors of nitric oxide synthase: B.R. Babu & O.W. Griffith; Curr. Opin. Chem. Biol. 2, 491 (1998), Abstract;

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
NOS Inhibitor
By catalog section:


Technical Service
Customer Service