Angiotensin-converting enzyme (ACE) inhibitor. Inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, yielding nitric oxide (NO) and the parent compound, captopril (Prod. No. ALX-270-212).
Product Details
| Alternative Name: | SNOCap |
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| Formula: | C9H14N2O4S |
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| MW: | 246.3 |
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| CAS: | 122130-63-6 |
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| Purity: | ≥98% |
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| Appearance: | Red crystals. |
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| Solubility: | Soluble in water or 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dynamics of interaction of vitamin C with some potent nitrovasodilators, S-nitroso-N-acetyl-d,l-penicillamine (SNAP) and S-nitrosocaptopril (SNOCap), in aqueous solution: D.V. Aquart & T.P. Dasgupta; Biophys. Chem.
107, 117 (2004),
Abstract;
S-nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats: D.Y. Tsui, et al.; J. Pharm. Pharmacol.
55, 1121 (2003),
Abstract;
S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats: D.Y. Tsui, et al.; Br. J. Pharmacol.
138, 855 (2003),
Abstract;
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S-nitrosylated captopril, a nitric oxide donor: L. Jia & H. Wong; Br. J. Pharmacol.
134, 1697 (2001),
Abstract;
Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor: L. Jia, et al.; Eur. J. Pharmacol.
391, 137 (2000),
Abstract;
Physicochemistry, pharmacokinetics, and pharmacodynamics of S-nitrosocaptopril crystals, a new nitric oxide donor: L. Jia, et al.; J. Pharm. Sci.
88, 981 (1999),
Abstract;
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats: L. Jia & R.C. Blantz; Eur. J. Pharmacol.
354, 33 (1998),
Abstract;
The effects of S-nitrosocaptopril on canine coronary circulation: I. Nakae, et al.; J. Pharmacol. Exp. Ther.
274, 40 (1995),
Abstract;
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin: T. Matsumoto, et al.; J. Pharmacol. Exp. Ther.
275, 1247 (1995),
Abstract;
Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide: M. Amano, et al.; J. Cardiovasc. Pharmacol.
24, 860 (1994),
Abstract;
Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier: J.W. Park; BBRC
189, 206 (1992),
Abstract;
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther.
256, 704 (1991),
Abstract;
S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets: J. Loscalzo, et al.; J. Pharmacol. Exp. Ther.
249, 726 (1989),
Abstract;
S-nitrosocaptopril. II. Effects on vascular reactivity: J.P. Cooke, et al.; J. Pharmacol. Exp. Ther.
249, 730 (1989),
Abstract;
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