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ACE inhibitor
ALX-270-213-M050 50 mg 360.00 USD
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Angiotensin-converting enzyme (ACE) inhibitor. Inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, yielding nitric oxide (NO) and the parent compound, captopril (Prod. No. ALX-270-212).

Product Details

Alternative Name:SNOCap
Appearance:Red crystals.
Solubility:Soluble in water or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Dynamics of interaction of vitamin C with some potent nitrovasodilators, S-nitroso-N-acetyl-d,l-penicillamine (SNAP) and S-nitrosocaptopril (SNOCap), in aqueous solution: D.V. Aquart & T.P. Dasgupta; Biophys. Chem. 107, 117 (2004), Abstract;
S-nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats: D.Y. Tsui, et al.; J. Pharm. Pharmacol. 55, 1121 (2003), Abstract;
S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats: D.Y. Tsui, et al.; Br. J. Pharmacol. 138, 855 (2003), Abstract;
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S-nitrosylated captopril, a nitric oxide donor: L. Jia & H. Wong; Br. J. Pharmacol. 134, 1697 (2001), Abstract;
Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor: L. Jia, et al.; Eur. J. Pharmacol. 391, 137 (2000), Abstract;
Physicochemistry, pharmacokinetics, and pharmacodynamics of S-nitrosocaptopril crystals, a new nitric oxide donor: L. Jia, et al.; J. Pharm. Sci. 88, 981 (1999), Abstract;
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats: L. Jia & R.C. Blantz; Eur. J. Pharmacol. 354, 33 (1998), Abstract;
The effects of S-nitrosocaptopril on canine coronary circulation: I. Nakae, et al.; J. Pharmacol. Exp. Ther. 274, 40 (1995), Abstract;
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin: T. Matsumoto, et al.; J. Pharmacol. Exp. Ther. 275, 1247 (1995), Abstract;
Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide: M. Amano, et al.; J. Cardiovasc. Pharmacol. 24, 860 (1994), Abstract;
Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier: J.W. Park; BBRC 189, 206 (1992), Abstract;
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther. 256, 704 (1991), Abstract;
S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets: J. Loscalzo, et al.; J. Pharmacol. Exp. Ther. 249, 726 (1989), Abstract;
S-nitrosocaptopril. II. Effects on vascular reactivity: J.P. Cooke, et al.; J. Pharmacol. Exp. Ther. 249, 730 (1989), Abstract;

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